ABSTRACT
Background: The advent of microbial drug resistance creates a concern about the quality of anti-infective drugs. The rise in some microbial resistance to therapy has urged us to investigate physico-chemical properties and antibacterial performance of amoxicillin from streets in Bamenda, Cameroon.Methods: Amoxicillin samples were purchased from street vendors in Bamenda. Cameroon. Visual inspection was done for defects and signs of discoloration, deterioration or other physical disfiguration. Weight uniformity test for each sample of antibiotic tablet was carried out. The time for drug disintegration for each sample of amoxicillin was evaluated. Microbial antibiotic susceptibility tests were done using both the agar disc diffusion and micro well broth dilution methods to check drug performance. Data analysis was done and comparison checked with Student-Newman-Keuls at p<0.05.Results: The mean weight of amoxicillin drugs ranged from 632.00±11.5 to 748.06±17.9 mg. Tablets from Austria had a significant decrease in weight compared to those from Germany and Nigeria. This was similar with the capsules from India and China. Average disintegration varied significantly from as small as 2.2 to 14.4 minutes. All the amoxicillin samples were active against the tested bacteria with mean zones of inhibitions ranging from 8.33±0.57 to 39.33±0.57 mm. The MICs and MBCs values range from 1 to 64 µg/ml. For the same bacterium the growth inhibitory effects of the various drugs were not all similar.Conclusions: Some of the amoxicillin samples studied in this paper showed significant differences in their weights and performances (antibacterial activities). Probably the required amount of API was not respected.
ABSTRACT
<p><b>OBJECTIVE</b>This study aimed to determine the effects of copper content on the corrosion resistance of CoCrMoCu alloy and its in vitro antibacterial performance.</p><p><b>METHODS</b>CoCrMoCu specimens with different Cu contents (2%, 3%, 5%, and 7%) were prepared by vacuum melting method. CoCrMo without Cu served as control. The corrosion resistance of the specimens was measured by electrochemistry. The antibacterial effects of the specimens on Staphylococcus aureus and Escherichia coli were analyzed by coating-film method.</p><p><b>RESULTS</b>Compared with CoCrMo without Cu, the addition of 2%-5% Cu to CoCrMo improved the pitting and uniform corrosion of CoCrMo alloy and decreased the corrosion current density. The antibacterial performance of CoCrMoCu alloy increased with increased Cu content. The antibacterial rate of alloy was 99% when Cu content exceeded 5%.</p><p><b>CONCLUSIONS</b>Cu addition had a statistically significant influence on the corrosion resistance and antibacterial performance of CoCrMoCu. CoCrMoCu has better corrosion resistance and antibacterial performance when Cu content is 5%.</p>